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Effect of long-term treatment with growth hormone on bone density and bone quality

Česká verze

Authors: Kužma Martin;  Stojkovičová Dáša;  Payer Juraj
Authors place of work: V. interná klinika LF UK a UNB, Nemocnica Ružinov, Bratislava
Published in the journal: Clinical Osteology 2019; 24(1): 23-26
Category: Přehledové články

Summary

Growth hormone (GH) affects bone metabolism directly by binding to GH receptor or indirectly by IGF-1. The anabolic effect of GH is essential for peak bone mass (PBM) and appropriate trabecular bone microarchitecture during adolescence and early adulthood. In short-term studies, the effect of GH replacement on bone mineral density (BMD) in adults with GH deficiency (GHD) was not observed. BMD increases are only observed in studies longer than 12–24 months. A gradual rise in BMD was then observed even after 5–7 years of GH treatment. At present, it is believed that impaired bone strength and microstructure is more important in fracture development than BMD. Although short-term studies have confirmed the positive effect of RH treatment on bone quality parameters, long-term data are insufficient.

Keywords:

bone mineral density – Growth hormone – peak bone mass

Zdroje
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Štítky
Biochemie Dětská gynekologie Dětská radiologie Dětská revmatologie Endokrinologie Gynekologie a porodnictví Interní lékařství Ortopedie Praktické lékařství pro dospělé Radiodiagnostika Rehabilitační a fyzikální medicína Revmatologie Traumatologie Osteologie
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Clinical Osteology

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