Reflection on the causes of senile osteoporosis
Authors:
Broulík Petr 1; Kočí Karolina 2
Authors place of work:
III. interní klinika – endokrinologie a metabolismu 1. LF UK a VFN v Praze
1; Interní klinika 1. LF UK a ÚVN – Vojenská fakultní nemocnice Praha
2
Published in the journal:
Clinical Osteology 2023; 28(1-2): 24-30
Category:
Přehledové články
Summary
Age is the last phase of life, which is difficult to define in which the involution, the sum of the involutive changes leads to the deterioration of the physical fitness, resistance and adaptability of the organism is more pronounced. The manifestation of physiological aging is worsening eyesight, peripheral neuropathy, depression, worsening of physical condition, skin aging, sarcopenia, bone mineral loss, and mobility disorders. We tried to find out on a small set of old women, without risk factors for osteoporosis, what caused them the loss of bone mineral found. We found that in addition to the loss of muscle, there was a decrease in bone mineral. Our women had a very low level of vitamin D that disrupted calcium absorption through the intestine, and decreased calcemia increased parathyroid hormone with its bone effect. Our women had low bone mineral turnover. Cause of minerals loss from bones of older women is multifactorial, with a number of factors alongside vitamin D and calcium resorption. In any case, senile osteoporosis, which is not caused by known risk factors for osteoporosis, (like early lost of sexual hormones) does not appear to be a separate disease, but is part of the physiological process of aging.
Keywords:
sarcopenia – old age – therapy – osteoporosis
Zdroje
1. Broulík P. Osteoporóza a její léčba. Maxdorf: Praha 2007. ISBN 978–80–7345–134–9.
2. Woods GN, Ewing SK, Sigurdsson S et al. Greater Bone Marrow Adiposity Predicts Bone Loss in Older Women. J Bone Miner Res 2020; 35(2): 326–332. Dostupné z DOI: <http://dx.doi.org/10.1002/jbmr.3895>.
3. Demontiero O, Vidal C, Duque G. Aging and bone loss: new insights for t he c linician. T her A dv M usculoskelet Dis 2 012; 4 (2): 61–76. Dostupné z DOI: <http://dx.doi.org/10.1177/1759720X11430858>.
4. Holick MF, Binkley NC, Bischoff-Ferrari HA et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocine society clinical practice guideline. J Clin Endocrinol Metab; 2011; 96(7): 1911–1930. Dostupné z DOI: <http://dx.doi.org/10.1210/jc.2011–0385>.
5. Remelli F, Vitali A , Zurlo A et al. Nutrients 2019; 11(12): 2861. Dostupné z DOI: <http://dx.doi.org/10.3390/nu11122861>.
6. Pfeifer M, Begerow B, Minne H et al. Efects of a long-term vitamin D and calcium supplementation on falls and parameters of muscle function in community-dwelling older individuals. Osteoporos Int 2009; 2 0(2): 3 15–322. D ostupné z DOI: < http://dx.doi.org/10.1007/s00198–008–0662–7>.
7. Falchetti A, Rossi A , Cosso R et al. Vitamin D and Bone Health. Food and Nutrition Sciences 2016; 7(11): 1033–1051. Dostupné z DOI: <http://dx.doi.org/10.4236/fns.2016.711100>.
8. Ferrari HA, Willett WC, Oray EJ et al. A pooled analysis of vitamin D dose requirement for fracture prevention. N Engl J Med 2012; 367(1): 40–78. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJMoa1109617>.
9. Cauley JA, Danielson ME, Boudreau R et al. Serum 25-Hydroxyvitamin D and clinical fracture risk in a multiethnic cohort of women: The Women’s Health Initiative (WHI). J Bone Miner Res 2011; 26(10): 2378–2388. Dostupné z DOI: <http://dx.doi.org/10.1002/jbmr.449>.
10. Cruz-Jentoft AJ, Baeyens JP, Bauer JM et al. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing 2010; 3 9(4): 4 12–423. D ostupné z DOI: < http://dx.doi.org/10.1093/ageing/afq034>.
11. Novotny SA, Warren GL, Hamrick MW et al. Aging and the Muscle-bone R elationship. P hysiology ( Bethesda) 2 015; 3 0(1): 8 –16. Dostupné z DOI: <http://dx.doi.org/10.1152/physiol.00033.2014>.
12. Laroche M, Ludor I, Thiechart M et al. Study of the intraosseous vessels of the femoral head in patients with fractures of the femoral neck or osteoarthritis of the hip. Osteoporos Int 1995; 5(4): 213–217. Dostupné z DOI: <http://dx.doi.org/10.1007/BF01774009>.
13. Broulik P, Kragstrup J, Mosekilde L et al. Osteon cross-sectional size in the iliac crest: variation in normals and patients with osteoporosis, hyperparathyroidism, acromegaly, hypothyroidism and treated epilepsia. Acta Pathol Microbiol Immunol Scand A. 1982; 90(5): 339–344.
14. Schousboe JT, Shepherd JA, Bilezikian JP et al. Executive Summary of the 2013 International Society for Clinical Densitometry Position. J Clin Densitom 2013; 16(4): 455–466. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jocd.2013.08.004>.
15. Kanis JA, Johansson H, Harvey NC et al. A brief history of FRAX. Arch Osteoporosis 2 018; 1 3(1): 118. Dostupné z DOI: < http://dx.doi.org/10.1007/s11657–018–0510–0>.
16. Gordon CM, Zemel BS, Wren TA et al The Determinants of peak bone mass. J Pediatr 2017; 180: 261–269. Dostupné z DOI: <http://dx.doi.org/10.1016/j.jpeds.2016.09.056>.
17. Dawson Hughes B, Heaney RP, Holick MF et al. Estimates of optimal v itamin D status. Osteoporosis I nt 2 005; 1 6(7): 7 13–716. Dostupné z DOI: <http://dx.doi.org/10.1007/s00198–005–1867–7>.
18. Hin H,Tomson J, Newman C et al. Optimum dose of vitamin D for disease prevention in older people. BEST-D trial of vitamin D in primary care. Osteoporosis Int 2017; 28(3): 841–851. Dostupné z DOI: <http://dx.doi.org/10.1007/s00198–016–3833-y>.
19. Francis RM. Calcium, vitamin D and involutional osteoporosis. Curr Opin Clin Nutr Metab Care 2006; 9(1): 13–17. Dostupné z DOI: <http://dx.doi.org/10.1097/01.mco.0000196140.95916.3a>.
20. Rizzoli R, Boone S, Brandi ML et al. Vitamin D suplementation in elderly or postmenopausal women: a 2013 update of the 2008 recommendations from the European Society for Clinical and Economic Aspects of osteoporosis and osteoarthritis (ESCEO). Curr Med Res Opin 2013; 29(4): 305–313. Dostupné z DOI: <http://dx.doi.org/10.1185/03007995.2013.766162>.
21. Black DM, Rosen CJ. Clinical Practice. Postmenopausal osteoporosis. N Engl J Med 2016; 374(3): 254–262. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJMcp1513724>.
22. Feskanich D, Willett W, Colditz G. Walking and leisure-time activity and risk of hip fracture in postmenopausal women. JAMA 2002; 288(18): 2300–2306. Dostupné z DOI: <http://dx.doi.org/10.1001/jama.288.18.2300>.
23. Boonen S, Dejaeger E, Vanderschueren D et al. Osteoporosis and osteoporotic fracture occurence and prevention in the elderly: a geriatric p erspective. Clin Endocrinol Metab 2008; 2 2(5): 765–785. Dostupné z DOI: <http://dx.doi.org/10.1016/j.beem.2008.07.002>.
24. Rizzoli R, Bruyere O, Cannata-Andia JB et al Management of osteoporosis in the elderly. Curr Med Res Opin 2009; 25(10): 2373–2387. Dostupné z DOI: <http://dx.doi.org/10.1185/03007990903169262>.
25. Vandenbroucke A, Luyten EP, Flamaing J et al. Pharmacological treatment of oseoporosis in oldest. Clin Intery Aging 2017; 12: 1065–1077. Dostupné z DOI: <http://dx.doi.org/10.2147/CIA.S131023>.
26. Lencel P, Magne D. Inflammaging: the driving force in osteoporosis? Med Hypothesis 2011; 76(3): 3 17–321. Dostupné z DOI: < http://dx.doi.org/10.1016/j.mehy.2010.09.023>.
27. Black DM, Delmas PD et al. Once yearly zoledronic acid for treatment of postmenopausal osteoporosis. N Engl J Med 2007; 356(18): 1809–1822. Dostupné z DOI: <http://dx.doi.org/10.1056/NEJMoa067312>.
28. Kannus P, Sievanen H, Palvanen M et al. Prevention of falls and consequent injuries in elderly people. Lancet 2004; 366(9500): 1885–1893. Dostupné z DOI: <http://dx.doi.org/10.1016/S0140–6736(05)67604–0>.
Štítky
Biochemie Dětská gynekologie Dětská radiologie Dětská revmatologie Endokrinologie Gynekologie a porodnictví Interní lékařství Ortopedie Praktické lékařství pro dospělé Radiodiagnostika Rehabilitační a fyzikální medicína Revmatologie Traumatologie OsteologieČlánek vyšel v časopise
Clinical Osteology
2023 Číslo 1-2
Nejčtenější v tomto čísle
- Exostóza proximálneho femuru – benígny nádor, „malígna“ lokalita: kazuistika
- Zamyšlení nad příčinami senilní osteoporózy
- Osteoporóza počas gravidity
- Jak a čím žije česká klinická osteologie v dnešní době